WASHINGTON - Gilles Simon beat second-seeded Andy Roddick 6-3, 6-3 on Thursday night in the third round of the Legg Mason Tennis Classic.

Roddick, a three-time champion of this U.S. Open Series event, came out flat against the 13th-seeded Frenchman in a match that started just before 11 p.m. ET because of a 4 1/2-hour weather delay.

Roddick, ranked ninth in the world, was the third highly seeded American to lose over the past two days.

Unseeded Xavier Malisse of Belgium beat fifth-seeded John Isner 6-4, 3-6, 7-6 (5) on Thursday. Sixth-seeded Sam Querrey lost in straight sets to Serbia's Janko Tipsarevic on Wednesday.